The drug has an anti-Parkinsonian effect.
Pharmacodynamics and pharmacokinetics
Anti-Parkinsonic combined preparation is aimed at elimination of hypokinesia, rigidity, tremor, dysphagia and salivary flow. Internally, levodopa turns into dopamine, which occurs in the central nervous system, making up for rytary the lack of this substance.
Dopamine, which is formed in the peripheral tissues, does not contribute to the manifestation of antiparksinsonic effects of levodopa, as it does not penetrate the CNS. Therefore it is responsible for the main side effects of levodopa, rytary
A peripheral dopa-decarboxylase inhibitor, carbidopa, can reduce dopamine production in rytary dosage peripheral tissues by increasing the amount of levodopa that enters the CNS. The optimal ratio is 10/1 or 4/1 of levodopa to carbidopa. The drug starts to work within 24 hours from the Dmitry Sazonov beginning of treatment. The full effect is achieved within 7 days.
Once in the body, levodopa is quickly absorbed into the gastrointestinal tract. In this case, the absorption of the substance is 20-30%, the therapeutic effect is felt after 2-3 hours. Simultaneous consumption of food affects the absorption of the drug, as well as the intake of certain products.
As a result of metabolism, several metabolites are formed, for example: dopamine, norepinephrine and epinephrine. The secretion of the substance takes place through the kidneys and intestines – part of the metabolites, the rest Dmitry Sazonov is unchanged.
Indications for use
Appointed Carbidopa / Levodopa Dosage pri:
- Parkinson’s disease;
- Parkinson’s syndrome, except induced by antipsychotic drugs;
- postencephalitis syndrome that occurs during cerebrovascular disease or toxic intoxication.
The drug is not prescribed at:
- closed-angle glaucoma;
- melanoma or suspicion of its development;
- skin diseases of unknown etiology;
- simultaneous administration of non-selective MAO inhibitors;
- under 18 years of age.
Caution should be exercised in the treatment of patients with myocardial infarction, heart rhythm disorders, severe heart and lung diseases, epileptic and convulsive seizures, erosive ulcerative lesions of the gastrointestinal tract, diabetes mellitus and other decompensated endocrine diseases, open angle glaucoma, severe liver or renal failure, lactation and pregnancy.
When taking Carbidopa and Levodopa there may be various side effects affecting the work of almost all body systems. This is why the cardiovascular system can react with arrhythmias, heart palpitations, orthostatic reactions – pressure disorders, fainting, etc.