Farmapram (alprazolam) is an anxiolytic drug with some antidepressant, hypnotic and anticonvulsant effects. Alprazolam increases inhibitory influence of gamma-aminobutyric acid in the central nervous system, increases sensitivity of GABA receptors to this mediator due to stimulation of benzodiazepine receptors of the supramolecular receptor complex GABA-benzodiazepine-chlorionophore. When taking farmapram, patients experience muscle relaxation. Alprazolam has some anticonvulsant activity.
The drug has a moderate sleeping effect, in particular, it facilitates falling asleep, increases the duration of sleep, and leads to a decrease in the number of nocturnal awakenings. The mechanism of Alprazolam’s sleeping pills is based on its ability to inhibit the reticular formation cells in the brain stem and to reduce the effects of vegetative, motor and emotional stimuli which negatively affect the process of falling asleep. When taking Alprazolam, patients have a decrease in symptoms of anxiety and fear, as well as a decrease in emotional tension. Farmapram (Alprazolam) has practically no effect on the cardiovascular as well as the respiratory system in healthy patients.
After oral administration, the active component is well absorbed in the digestive tract and reaches peak plasma concentrations within 1-2 hours. The bioavailability of Alprazolam is about 80%. Plasma concentrations increase proportionally with increasing doses of alprazolam. About 80% of the dose taken is bound to plasma proteins. Alprazolam penetrates the blood-placental and blood-brain barrier and is detected in breast milk. Equilibrium concentrations of alprazolam in plasma are established on the second or third day of therapy. It is metabolized mainly in the liver to form the pharmacologically active substance (alpha-hydroxyl metabolite). It is excreted mainly by the kidneys in the form of compounds with glucuronic acid; the elimination half-life of alprazolam reaches 11-16 hours. Alprazolam practically does not cumulate in the body.
Indications for use
Farmapram (Alprazolam) is used for the therapy of patients with neurotic and neurosis-like disorders which are accompanied by feelings of anxiety and restlessness. Alprazolam may be prescribed to patients with reactive depressive states including those developed against the background of somatic diseases.
Alprazolam can be used to treat patients with panic disorders, insomnia and withdrawal syndrome (including alcohol and drug withdrawal syndrome).
Directions for use
Alprazolam is intended for oral administration. The drug Alprazolam is taken regardless of meals. As a rule, it is recommended to divide the daily dose into 2-3 doses. The duration of therapy and doses of alprazolam are determined individually. When selecting a dose, the patient’s condition, tolerability of alprazolam should be carefully monitored and, taking into account the effect achieved, the dose should be adjusted.